Neuroprotective effects of bone marrow Sca-1⁺ cells against age-related retinal degeneration in OPTN E50K mice.

ABSTRACT: Glaucoma is characterized by retinal ganglion cell (RGC) death, the underlying mechanisms of which are still largely unknown. An E50K mutation in the Optineurin (OPTN) gene is a leading cause of normal-tension glaucoma (NTG), which directly affects RGCs in the absence of high intraocular pressure and causes severe glaucomatous symptoms in patients. Bone marrow (BM) stem cells have been demonstrated to play a key role in regenerating damaged tissue during ageing and disease through their trophic effects and homing capability. Here, we separated BM stem cells into Sca-1⁺ and Sca-1^- cells and transplanted them into lethally irradiated aged OPTN E50K mice to generate Sca-1⁺ and Sca-1^- chimaeras, respectively. After 3 months of BM repopulation, we inv

SUBMITTER: Liu X 

PROVIDER: S-EPMC8203676 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature