Integrated omics endotyping of infants with respiratory syncytial virus bronchiolitis and risk of childhood asthma.

ABSTRACT: Respiratory syncytial virus (RSV) bronchiolitis is not only the leading cause of hospitalization in U.S. infants, but also a major risk factor for asthma development. While emerging evidence suggests clinical heterogeneity within RSV bronchiolitis, little is known about its biologically-distinct endotypes. Here, we integrated clinical, virus, airway microbiome (species-level), transcriptome, and metabolome data of 221 infants hospitalized with RSV bronchiolitis in a multicentre prospective cohort study. We identified four biologically- and clinically-meaningful endotypes: A) clinical^classicmicrobiome^{M. nonliquefaciens}inflammation^{IFN-intermediate}, B) clinical^atopicmicrobiome^{S. pneumoniae/M. catarrhalis}inflammation^IFN-high, C)

SUBMITTER: Raita Y 

PROVIDER: S-EPMC8203688 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature