Life-course trajectories of weight and their impact on the incidence of type 2 diabetes.

ABSTRACT: Although exposure to overweight and obesity at different ages is associated to a higher risk of type 2 diabetes, the effect of different patterns of exposure through life remains unclear. We aimed to characterize life-course trajectories of weight categories and estimate their impact on the incidence of type 2 diabetes. We categorized the weight of 7203 participants as lean, normal or overweight at five time-points from ages 7-55 using retrospective data. Participants were followed for an average of 19 years for the development of type 2 diabetes. We used latent class analysis to describe distinctive trajectories and estimated the risk ratio, absolute risk difference and population attributable fraction (PAF) associated to different trajectories using Poisson regression. We found five dist

SUBMITTER: Yacaman-Mendez D 

PROVIDER: S-EPMC8203741 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature