Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells.

ABSTRACT: Lung adenocarcinoma is heterogeneous and hierarchically organized, with a subpopulation of stem-like cells (CSCs) that reside at the apex of the hierarchy, in which exosomes act as important mediators by transporting specific molecules among different cell populations. Although there have been numerous studies on tumor exosomes, the constituents and functional properties of CSC-derived exosomes are still poorly characterized. Here we present a detail transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells (LSLCs). The transcriptome analysis indicates the specific patterns of exosomal constituents, including the fragmentation of transcripts and the low-level presence of circular RNAs, and identifies multiple exosomal-enriched mRNAs and lncRNAs.

SUBMITTER: Luo HT 

PROVIDER: S-EPMC8203745 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature