A novel therapeutic HBV vaccine candidate induces strong polyfunctional cytotoxic T cell responses in mice.

ABSTRACT:

Background & aims

Current standard-of-care suppresses HBV replication, but does not lead to a functional cure. Treatment aiming to cure chronic hepatitis B (CHB) is believed to require the induction of strong cellular immune responses, such as by therapeutic vaccination.

Methods

We designed a therapeutic HBV vaccine candidate (YF17D/HBc-C) using yellow fever vaccine YF17D as a live-attenuated vector to express HBV core antigen (HBc). Its ability to induce potent cellular immune responses was assessed in a mouse model that supports flavivirus replication.

Results

Following a HBc protein prime, a booster of YF17D/HBc-C was found to induce vigorous cytotoxic T cell responses. In a direct head-to-head comparison, these HBc-specific responses exceeded those elicited by ade

SUBMITTER: Boudewijns R 

PROVIDER: S-EPMC8203848 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature