The Efficacy and Safety of Esmolol for Septic Shock: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

ABSTRACT: Purpose: The meta-analysis aims to identify whether septic shock patients can benefit from esmolol. Materials and Methods: The relevant studies from MEDLINE, Cochrane Library, Embase were searched by two independent investigators using a variety of keywords. Stata software (version 12.0, Stata Corp LP, College Station, TX, United States)was used for statistical analysis. Results: A total of 14 studies were identified and incorporated into the meta-analysis. For overall analysis, the treatment of esmolol was associated with decreased 28-day mortality (RR = 0.66, 95% CI = 0.56-0.77, p < 0.001). Meanwhile, our analysis found that, esmolol could decrease HR (SMD: -1.70; 95% CI: [-2.24-(-1.17)], cTnI (SMD: -1.61; 95% CI: [-2.06-(-1.16)] compared with standard treatme

SUBMITTER: Huang P 

PROVIDER: S-EPMC8204042 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature