Chronic Jet Lag Exacerbates Jejunal and Colonic Microenvironment in Mice.

ABSTRACT:

Background

Evidence suggests that circadian rhythm disorder is associated with a variety of gastrointestinal diseases, and the circadian rhythm plays a key role in maintaining the homeostasis of intestinal flora. The underlying mechanisms are still not completely identified. This study was aimed to explore whether jet lag-caused circadian disruption influences gut microbiome and its metabolites.

Methods

Mice were synchronized with 12-h light/dark cycles (control group) or subjected to daily 8-h advance of the light/dark cycle for every 3 days (jet-lagged group). Four months later, fecal samples and jejunal contents were collected and analyzed by 16S rRNA gene sequencing. In addition, fecal samples were subjected to metabolome analysis with ultra-performance liquid chromatogr

SUBMITTER: Li Q 

PROVIDER: S-EPMC8204051 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature