CD22 Blockage Restores Age-Related Impairments of Microglia Surveillance Capacity.

ABSTRACT: Microglia, the innate immune cells of the brain, are essential for maintaining homeostasis by their ramified, highly motile processes and for orchestrating the immune response to pathological stimuli. They are implicated in several neurodegenerative diseases like Alzheimer's and Parkinson's disease. One commonality of these diseases is their strong correlation with aging as the highest risk factor and studying age-related alterations in microglia physiology and associated signaling mechanism is indispensable for a better understanding of age-related pathomechanisms. CD22 has been identified as a modifier of microglia phagocytosis in a recent study, but not much is known about the function of CD22 in microglia. Here we show that CD22 surface levels are upregulated in aged versus adult micro

SUBMITTER: Aires V 

PROVIDER: S-EPMC8204252 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature