Alternative splicing associated with cancer stemness in kidney renal clear cell carcinoma.

ABSTRACT:

Backgroud

Cancer stemness is associated with metastases in kidney renal clear cell carcinoma (KIRC) and negatively correlates with immune infiltrates. Recent stemness evaluation methods based on the absolute expression have been proposed to reveal the relationship between stemness and cancer. However, we found that existing methods do not perform well in assessing the stemness of KIRC patients, and they overlooked the impact of alternative splicing. Alternative splicing not only progresses during the differentiation of stem cells, but also changes during the acquisition of the stemness features of cancer stem cells. There is an urgent need for a new method to predict KIRC-specific stemness more accurately, so as to provide help in selecting treatment options.

Methods

The cor

SUBMITTER: Xiao L 

PROVIDER: S-EPMC8204412 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature