Maintenance of the human memory T cell repertoire by subset and tissue site.

ABSTRACT:

Background

Immune-mediated protection is mediated by T cells expressing pathogen-specific T cell antigen receptors (TCR) that are maintained at diverse sites of infection as tissue-resident memory T cells (TRM) or that disseminate as circulating effector-memory (TEM), central memory (TCM), or terminal effector (TEMRA) subsets in blood and tissues. The relationship between circulating and tissue resident T cell subsets in humans remains elusive, and is important for promoting site-specific protective immunity.

Methods

We analyzed the TCR repertoire of the major memory CD4⁺ and CD8⁺T cell subsets (TEM, TCM, TEMRA, and TRM) isolated from blood and/or lymphoid organs (spleen, lymph nodes, bone marrow) and lungs of nine organ donors, and blood of three livin

SUBMITTER: Miron M 

PROVIDER: S-EPMC8204429 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature