The Early Diagnostic Value of Serum Interleukin-8 in Esophagogastric Junction Adenocarcinoma.

ABSTRACT:

Background

Esophagogastric junction adenocarcinoma (EJA) is one of the most common malignant tumors of digestive tract with high mortality worldwide. Given a lack of early diagnosis biomarkers, the prognosis of EJA is poor. Non-invasive biomarkers for early-stage EJA are urgently required.

Objective

We aimed at evaluating the early diagnostic value of serum interleukin-8 (IL-8) level in EJA patients.

Methods

The IL-8 mRNA expression data were analyzed based on the stomach cardia adenocarcinoma samples of The Cancer Genome Atlas (TCGA) database. Enzyme-linked immunosorbent assay (ELISA) was used to measure the concentration of serum IL-8 in 95 EJA patients and 95 normal controls enrolled from 2 different cancer hospitals. The diagnostic accuracy of serum IL-8 was evalu

SUBMITTER: Li Z 

PROVIDER: S-EPMC8204455 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature