Ovary-derived circular RNAs profile analysis during the onset of puberty in gilts.

ABSTRACT:

Background

In mammals, the ovary is the essential system of female reproduction for the onset of puberty, and the abnormal puberty has negative outcomes on health. CircRNA is a non-coding RNA produced by non-canonical alternative splicing (AS). Several studies have reported that circRNA is involved in the gene regulation and plays an important role in some human diseases. However, the contribution of circRNA has received little known within the onset of puberty in ovary.

Results

Here, the profiles of ovarian circRNAs across pre-, in- and post-pubertal stages were established by RNA-sEq. In total, 972 circRNAs were identified, including 631 stage-specific circRNAs and 8 tissue-specific circRNAs. The biological functions of parental genes of circRNAs were enriched in steroid b

SUBMITTER: Pan X 

PROVIDER: S-EPMC8204460 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature