Short-term preoperative protein restriction attenuates vein graft disease via induction of cystathionine γ-lyase.

ABSTRACT:

Aims

Therapies to prevent vein graft disease, a major problem in cardiovascular and lower extremity bypass surgeries, are currently lacking. Short-term preoperative protein restriction holds promise as an effective preconditioning method against surgical stress in rodent models, but whether it can improve vein graft patency after bypass surgery is undetermined. Here, we hypothesized that short-term protein restriction would limit vein graft disease via up-regulation of cystathionine γ-lyase and increased endogenous production of the cytoprotective gaseous signalling molecule hydrogen sulfide.

Methods and results

Low-density lipoprotein receptor knockout mice were preconditioned for 1 week on a high-fat high-cholesterol (HFHC) diet with or without protein prior to left common

SUBMITTER: Trocha KM 

PROVIDER: S-EPMC8204489 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature