Integrated analysis of the functions and prognostic values of RNA binding proteins in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC), one of the most common malignant tumors worldwide, ranks as the fifth most common cancer and has been the second most frequent cause of cancer-related death. RNA binding proteins (RBPs) are proteins that interact with different classes of RNA and are commonly detected in cells.

Methods

We used RNA sequencing data from TCGA to display dysfunctional RBPs microenvironments and provide potential useful biomarkers for HCC diagnosis and prognosis.

Results

330 differently expressed RBPs (208 upregulated and 122 downregulated) were identified. KEGG were mainly enriched in RNA degradation, Influenza A, Hepatitis C, RIG-I-like receptor signaling pathway, Herpes simplex virus 1 infection and RNA transport. CBioPortal results demonstrate

SUBMITTER: Wu ZH 

PROVIDER: S-EPMC8204501 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature