Antibiotic perturbation of the murine gut microbiome introduces inter-individual susceptibility to arsenic.

ABSTRACT: Arsenic is a Group 1 human carcinogen and at least 200 million people around the world are exposed to unsafe levels of arsenic, predominantly through contaminated drinking water. Arsenic has also been used for hundreds, if not thousands, of years as an intentional poison due to its odorless/tasteless properties and the general lack of technology required to identify it. Both acute and chronic arsenic-related health outcomes are highly variable among similarly exposed individuals even after controlling for important factors, like host genetics, making the mechanisms underlying this often-made epidemiologic observation difficult to experimentally address and not fully understood. Here, we describe an experimental model of arsenic exposure in C57BL/6 mice that recapitulates key aspects of int

SUBMITTER: Roggenbeck BA 

PROVIDER: S-EPMC8204511 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature