Utilization of the evidence from studies with no events in meta-analyses of adverse events: an empirical investigation.

ABSTRACT:

Backgrounds

Zero-events studies frequently occur in systematic reviews of adverse events, which consist of an important source of evidence. We aimed to examine how evidence of zero-events studies was utilized in the meta-analyses of systematic reviews of adverse events.

Methods

We conducted a survey of systematic reviews published in two periods: January 1, 2015, to January 1, 2020, and January 1, 2008, to April 25, 2011. Databases were searched for systematic reviews that conducted at least one meta-analysis of any healthcare intervention and used adverse events as the exclusive outcome. An adverse event was defined as any untoward medical occurrence in a patient or subject in healthcare practice. We summarized the frequency of occurrence of zero-events studies in eligible

SUBMITTER: Xu C 

PROVIDER: S-EPMC8204528 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature