Inter-rater reliability of subthreshold psychotic symptoms in individuals with 22q11.2 deletion syndrome.

ABSTRACT:

Background

Pathways leading to psychosis in 22q11.2 deletion syndrome (22q11.2DS) have been the focus of intensive research during the last two decades. One of the common clinical risk factors for the evolution of psychosis in 22q11.2DS is the presence of positive and negative subthreshold psychotic symptoms. The gold standard for measuring subthreshold symptoms is the Structured Interview for Prodromal Syndromes (SIPS) and its accompanying Scale of Prodromal Symptoms (SOPS) ratings. Although the scale has been used by many centers studying 22q11.2DS, the inter-site reliability of the scale in this population has never been established.

Methods

In the present study, experienced clinical assessors from three large international centers studying 22q11.2DS independently rated v

SUBMITTER: Moore TM 

PROVIDER: S-EPMC8204529 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature