Metronidazole-associated Neurologic Events: A Nested Case-control Study.

ABSTRACT:

Background

Case reports have described instances of peripheral and central nervous system toxicity during treatment with metronidazole; however, no large-scale studies have examined this association.

Methods

We conducted a population-based nested case-control study of adults aged 66 years or older living in Ontario, Canada, between 1 April 2003 and 31 March 2017. Cases were individuals who attended hospital for any of cerebellar dysfunction, encephalopathy, or peripheral neuropathy within 100 days of a prescription for either metronidazole or clindamycin. We matched each case patient with up to 10 event-free control subjects who also received metronidazole or clindamycin. We used conditional logistic regression to test the association between metronidazole exposure and neuro

SUBMITTER: Daneman N 

PROVIDER: S-EPMC8204771 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature