Hedgehog Signaling Demarcates a Niche of Fibrogenic Peribiliary Mesenchymal Cells.

ABSTRACT:

Background & aims

In response to tissue injury, stromal cells secrete extracellular matrix (ECM) components that remodel the tissue and lead to fibrosis. Parenchymal stellate cells are the primary contributors to fibrosis in models of hepatocellular and cholestatic injury. The liver comprises different, heterogenous compartments; stromal cells within those compartments might have unique identities and regional functions. The portal tract contains the bile duct, which is surrounded by stromal cells often called portal fibroblasts. We investigated the contributions of these cells to hepatic injury.

Methods

We performed studies with Gli1:Cre^ERT2;Rosa26:lox-STOP-lox-tdTomato mice. Mice underwent bile duct ligation or were fed 3,5-diethoxycarbonyl-1,4-dihydrocollidine

SUBMITTER: Gupta V 

PROVIDER: S-EPMC8204800 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature