A novel method for the laboratory workup of anaphylactic transfusion reactions in haptoglobin-deficient patients.

ABSTRACT:

Background

Patients with congenital haptoglobin deficiency can develop anti-haptoglobin antibodies after exposure to blood products, and they can suffer from life-threatening anaphylactic transfusion reactions. Here, we present a case of a 57-year-old Chinese male with myelodysplastic syndrome who manifested an anaphylactic transfusion reaction during the transfusion of platelets. The only abnormality detected during his reaction laboratory workup was an undetectable haptoglobin level in the absence of evidence of hemolysis.

Study design and methods

Surface plasmon resonance (SPR) was explored as a method to be able to detect the presence of anti-haptoglobin antibodies in serum. First, haptoglobin was immobilized to the surface of an SPR sensor chip. The patient's serum samp

SUBMITTER: Thoren KL 

PROVIDER: S-EPMC8204907 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature