Comparability of thyroid-stimulating hormone immunoassays using fresh frozen human sera and external quality assessment data.

ABSTRACT:

Background

This study aimed to assess the comparability among assays using freshly frozen human sera and external quality assessment (EQA) data in China.

Methods

Twenty-nine serum samples and two commercial EQA materials, obtained from the National Center for Clinical Laboratories (NCCL), were analyzed in triplicate using eight routine TSH assays. The commutability of commercial EQA materials (NCCL materials) was evaluated in accordance with the CLSI EP30-A and IFCC bias analysis. Median values obtained for the NCCL EQA materials were used to determine the systematic and commutability-related biases among immunoassays through back-calculation. The comparability of TSH measurements from a panel of clinical samples and NCCL EQA data was determined on the basis of Passing-Bablo

SUBMITTER: Zhang S 

PROVIDER: S-EPMC8205121 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature