Induction of Neurogenesis and Angiogenesis in a Rat Hemisection Spinal Cord Injury Model With Combined Neural Stem Cell, Endothelial Progenitor Cell, and Biomimetic Hydrogel Matrix Therapy.

ABSTRACT: Acute spinal cord injury is a devastating injury that may lead to loss of independent function. Stem-cell therapies have shown promise; however, a clinically efficacious stem-cell therapy has yet to be developed. Functionally, endothelial progenitor cells induce angiogenesis, and neural stem cells induce neurogenesis. In this study, we explored using a multimodal therapy combining endothelial progenitor cells with neural stem cells encapsulated in a bioactive biomimetic hydrogel matrix to facilitate stem cell-induced neurogenesis and angiogenesis in a rat hemisection spinal cord injury model.

Design

Laboratory experimentation.

Setting

University laboratory.

Subjects

Female Fischer 344 rats.

Interventions

Three groups of rats: 1) control, 2) biomimetic hydrogel t

SUBMITTER: Marrotte EJ 

PROVIDER: S-EPMC8205216 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature