[11C]PK11195-PET Brain Imaging of the Mitochondrial Translocator Protein in Mitochondrial Disease.

ABSTRACT:

Objective

To explore the possibilities of radioligands against the mitochondrial outer membrane protein TSPO as biomarkers for mitochondrial disease, we performed PET (PET)-MR brain imaging with [¹¹C]PK11195 in 14 patients with genetically confirmed mitochondrial disease and 33 matched controls.

Methods

A case-control study of PET-MR imaging with the TSPO radioligand [¹¹C]PK11195.

Results

Forty-six percent of symptomatic patients had volumes of abnormal radiotracer binding greater than the 95th percentile in controls. [¹¹C]PK11195 binding was generally greater in grey matter and significantly decreased in white matter. This was most striking in patients with nuclear TYMP or mitochondrial m.3243A>G MT-TL1 mutations, in kee

SUBMITTER: van den Ameele J 

PROVIDER: S-EPMC8205464 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature