Association of Hemoglobin A1C With TDP-43 Pathology in Community-Based Elders.

ABSTRACT:

Objective

We tested the hypothesis that an inverse association exists between diabetes mellitus (DM) and hemoglobin A1C (A1C) with Transactive response DNA binding protein 43 (TDP-43) levels in older adults.

Methods

We leveraged antemortem and postmortem data of decedents from three community-based clinical-pathological studies. DM status, A1C levels, and medications for DM were documented annually. TDP-43 cytoplasmic inclusions, evaluated in 6 brain regions using immunohistochemistry, were used to obtain a semiquantitative TDP-43 score (0-5) in each region, and scores were averaged across regions to obtain a TDP-43 severity score. We used linear regressions to test the association of DM and A1C with the TDP-43 severity score.

Results

On average, participants (n=817)

SUBMITTER: Oveisgharan S 

PROVIDER: S-EPMC8205465 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature