Association Between Hemostatic Profile and Migraine: A Mendelian Randomization Analysis.

ABSTRACT:

Objective

To assess support for a causal relationship between hemostatic measures and migraine susceptibility using genetic instrumental analysis.

Methods

Two-sample Mendelian randomization instrumental analyses leveraging available genome-wide association study (GWAS) summary statistics were applied to hemostatic measures as potentially causal for migraine and its subtypes, migraine with aura (MA) and migraine without aura (MO). Twelve blood-based measures of hemostasis were examined, including plasma level or activity of 8 hemostatic factors and 2 fibrinopeptides together with 2 hemostasis clinical tests.

Results

There were significant instrumental effects between increased coagulation factor VIII activity (FVIII; odds ratio [95% confidence interval] 1.05 [1.03, 1.0

SUBMITTER: Guo Y 

PROVIDER: S-EPMC8205479 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature