Uromodulin (Tamm-Horsfall protein): guardian of urinary and systemic homeostasis.

ABSTRACT: Biology has taught us that a protein as abundantly made and conserved among species as Tamm-Horsfall protein (THP or uromodulin) cannot just be a waste product serving no particular purpose. However, for many researchers, THP is merely a nuisance during urine proteome profiling or exosome purification and for clinicians an enigmatic entity without clear disease implications. Thanks to recent human genetic and correlative studies and animal modeling, we now have a renewed appreciation of this highly prevalent protein in not only guarding urinary homeostasis, but also serving as a critical mediator in systemic inter-organ signaling. Beyond a mere barrier that lines the tubules, or a surrogate for nephron mass, mounting evidence suggests that THP is a multifunctional protein critical for modu

SUBMITTER: Micanovic R 

PROVIDER: S-EPMC8205501 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature