Identification of Critical m⁶A RNA Methylation Regulators with Prognostic Value in Lower-Grade Glioma.

ABSTRACT: Increasing evidences have revealed that N⁶-methyladenosine (m⁶A) RNA methylation regulators participate in the tumorigenesis and development of multiple tumors. So far, there has been little comprehension about the effects of m⁶A RNA methylation regulators on lower-grade gliomas (LGG). Here, we systematically investigated the expression profiles and prognostic significance of 36 m⁶A RNA methylation regulators in LGG patients from the TCGA and CGGA databases. Most of the m⁶A RNA methylation regulators are differentially expressed in LGG tissues as compared with normal brain tissues and glioblastoma (GBM) tissues. The consensus clustering for these m⁶A RNA methylation regulators identified three clusters. Patients in cluster 3

SUBMITTER: Zheng J 

PROVIDER: S-EPMC8205593 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature