A mouse model of endometriosis mimicking the natural spread of invasive endometrium.

ABSTRACT:

Study question

Is it possible to establish a genetically engineered mouse model (GEMM) of endometriosis that mimics the natural spread of invasive endometrium?

Summary answer

Endometriosis occurs in an ARID1A (AT-rich interactive domain-containing protein 1A) and PIK3CA (phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha) mutant GEMM of endometrial dysfunction following salpingectomy.

What is known already

Although mouse models of endometriosis have long been established, most models rely on intraperitoneal injection of uterine fragments, steroid hormone treatments or the use of immune-compromised mice.

Study design, size, duration

Mice harboring the lactotransferrin-Cre (LtfCre0/+), Arid1afl, (Gt)R26Pik3ca*H1047R and (Gt)R26mTmG alleles we

SUBMITTER: Wilson MR 

PROVIDER: S-EPMC8205619 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature