Crohn's Disease Is Associated With Activation of Circulating Innate Lymphoid Cells.

ABSTRACT:

Background

Inflammatory bowel disease (IBD) is associated with disturbed mucosal innate lymphoid cell (ILC) composition, which is correlated to the degree of intestinal inflammation. However, it remains unclear whether circulating ILCs are dysregulated in patients with IBD.

Methods

Blood samples from 53 patients with Crohn's disease (CD), 43 patients with ulcerative colitis (UC), and 45 healthy control subjects (HC) were analyzed by flow cytometry for markers of ILC subsets (ILC1, ILC2, and ILC precursors [ILCp]) and selected IBD-relevant proteins, as predicted by previous genome-wide association studies. A dimensionality reduction approach to analyzing the data was used to characterize circulating ILCs.

Results

The frequency of ILCp expressing the ILC3 activation mar

SUBMITTER: Mazzurana L 

PROVIDER: S-EPMC8205634 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature