Anatomic changes in head and neck intensity-modulated proton therapy: Comparison between robust optimization and online adaptation.

ABSTRACT:

Background/purpose

Setup variations and anatomical changes can severely affect the quality of head and neck intensity-modulated proton therapy (IMPT) treatments. The impact of these changes can be alleviated by increasing the plan's robustness a priori, or by adapting the plan online. This work compares these approaches in the context of head and neck IMPT.

Materials/methods

A representative cohort of 10 head and neck squamous cell carcinoma (HNSCC) patients with daily cone-beam computed tomography (CBCT) was evaluated. For each patient, three IMPT plans were created: 1- a classical robust optimization (cRO) plan optimized on the planning CT, 2- an anatomical robust optimization (aRO) plan additionally including the two first daily CBCTs and 3- a plan optimized without robus

SUBMITTER: Lalonde A 

PROVIDER: S-EPMC8205952 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature