The impact of obstructive sleep apnea on bronchiolitis severity in children with Down syndrome.

ABSTRACT:

Objectives

Acute bronchiolitis commonly causes respiratory failure in children ≤2 years, and is particularly severe in those with Down syndrome (DS). Obstructive sleep apnea (OSA), common in DS, is also associated with respiratory complications. However, it is unknown whether OSA is associated with worse outcomes in children with and without DS, hospitalized with bronchiolitis. We hypothesized that in children with bronchiolitis, OSA is associated with worse outcomes in those with DS, independent of DS-related comorbidities.

Methods

Hospital discharge records of children with bronchiolitis aged ≤2 years were obtained for 1997-2012 from the Kid's Inpatient Database. The primary outcome was invasive mechanical ventilation (IMV), and secondary outcomes were non-invasive mechani

SUBMITTER: Tsou PY 

PROVIDER: S-EPMC8205980 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature