Identifying the Lipidomic Effects of a Rare Loss-of-Function Deletion in <i>ANGPTL3</i>.

ABSTRACT:

Background

The identification and understanding of therapeutic targets for atherosclerotic cardiovascular disease is of fundamental importance given its global health and economic burden. Inhibition of ANGPTL3 (angiopoietin-like 3) has demonstrated a cardioprotective effect, showing promise for atherosclerotic cardiovascular disease treatment, and is currently the focus of ongoing clinical trials. Here, we assessed the genetic basis of variation in ANGPTL3 levels in the San Antonio Family Heart Study.

Methods

We assayed ANGPTL3 protein levels in ≈1000 Mexican Americans from extended pedigrees. By drawing upon existing plasma lipidome profiles and genomic data we conducted analyses to understand the genetic basis to variation in ANGPTL3 protein levels, and accordingly the cor

SUBMITTER: Blackburn NB 

PROVIDER: S-EPMC8206021 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature