Gene variants associated with obstructive sleep apnea (OSA) in relation to sudden infant death syndrome (SIDS).

ABSTRACT:

Background

Both obstructive sleep apnea (OSA) and (at least a fraction of) sudden infant death syndrome (SIDS) are associated with impaired respiration. For OSA, an association with several gene variants was identified. Therefore, our hypothesis is that these polymorphisms might be of relevance in SIDS as well.

Methods

Twenty-four single nucleotide polymorphisms (SNPs) in 21 candidate genes connected to OSA, were genotyped in a total of 282 SIDS cases and 374 controls. Additionally, subgroups based on factors codetermining the SIDS risk (age, sex, season, and prone position) were established and compared as well.

Results

Two of the analyzed SNPs showed nominally significant differences between SIDS and control groups: rs1042714 in ADRB2 (adrenoceptor beta 2) and rs180

SUBMITTER: Kerz J 

PROVIDER: S-EPMC8206047 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature