A Noninvasive Ultrasound Based Technique to Identify Treatment Responders in Patients with Portal Hypertension.

ABSTRACT:

Rationale and objective

Subharmonic aided pressure estimation (SHAPE) is based on the inverse relationship between the subharmonic amplitude of ultrasound contrast microbubbles and ambient pressure. The aim of this study was to verify if SHAPE can accurately monitor disease progression in patients identified with portal hypertension.

Materials & methods

A modified Logiq 9 scanner with a 4C curvi-linear probe (GE, Waukesha, WI) was used to acquire SHAPE data (transmitting and receiving at 2.5 and 1.25 MHz, respectively) using Sonazoid (GE Healthcare, Oslo, Norway; FDA IND 124,465). Twenty-one (median age 59 years; 12 Males) of the 178 patients enrolled in this institutional review board approved study (14F.113) were identified as having clinically significant portal hypertens

SUBMITTER: Gupta I 

PROVIDER: S-EPMC8206222 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature