Development and external validation of a novel nomogram for screening Chinese Lynch syndrome: based on a multicenter, population study.

ABSTRACT:

Background

This multicenter study aimed to reveal the genetic spectrum of colorectal cancer (CRC) with deficient mismatch repair (dMMR) and build a screening model for Lynch syndrome (LS).

Methods

Through the immunohistochemical (IHC) screening of mismatch repair protein results in postoperative CRC patients, 311 dMMR cases, whose germline and somatic variants were detected using the ColonCore panel, were collected. Univariate and multivariate logistic regression analysis was performed on the clinical characteristics of these dMMR individuals, and a clinical nomogram, incorporating statistically significant factors identified using multivariate logistic regression analysis, was constructed to predict the probability of LS. The model was validated externally by an independent

SUBMITTER: Yang M 

PROVIDER: S-EPMC8207298 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature