Identification of a Locus on the X Chromosome Linked to Familial Membranous Nephropathy.

ABSTRACT:

Introduction

Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in adults and is a leading cause of end-stage renal disease due to glomerulonephritis. Primary MN has a strong male predominance, accounting for approximately 65% of cases; yet, currently associated genetic loci are all located on autosomes. Previous reports of familial MN have suggested the existence of a potential X-linked susceptibility locus. Identification of such risk locus may provide clues to the etiology of MN.

Methods

We identified 3 families with 8 members affected by primary MN. Genotyping was performed using single-nucleotide polymorphism microarrays, and serum was sent for anti-phospholipase A2 receptor (PLA2R) antibody testing. All affected members were male and connec

SUBMITTER: Downie ML 

PROVIDER: S-EPMC8207324 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature