A Systematic Review of Renal Pathology in Chronic Kidney Disease of Uncertain Etiology.

ABSTRACT:

Introduction

Despite much research on chronic kidney disease of uncertain etiology (CKDu) in Sri Lanka and the Mesoamerican nephropathy, the etiology and pathogenesis of this disease remains elusive. The pathology has broadly been described as chronic tubulointerstitial nephritis and no specific signature lesions have been identified.

Methods

A scoping review was conducted through MEDLINE and Google Scholar databases for peer-reviewed publications on biopsy studies related to CKDu - Sri Lanka and Mesoamerican nephropathy to develop a comparative and critical analysis of the renal pathology found in these patients.

Results

Thirteen studies met the selection criteria. Interstitial fibrosis was the predominant lesion in all the studies. Tubulointerstitial and glomerular

SUBMITTER: Gunawardena S 

PROVIDER: S-EPMC8207327 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature