On Path to Informing Hierarchy of Eplet Mismatches as Determinants of Kidney Transplant Loss.

ABSTRACT:

Introduction

To mitigate risks related to human leukocyte antigen (HLA) incompatibility, we assessed whether certain structurally defined HLA targets present in donors but absent from recipients, known as eplet mismatches (EMM), are associated with death-censored graft failure (DCGF).

Methods

We studied a cohort of 118,313 American 0% panel reactive antibodies (PRA) first kidney transplant recipients (2000 to 2015) from the Scientific Registry of Transplant Recipients. Imputed allele-level donor and recipient HLA-A, -B, -C, -DRB1, and -DQB1 genotypes were converted to the repertoire of EMM. We fit survival models for each EMM with significance thresholds corrected for false discovery rate and validated those in an independent PRA > 0% cohort. We conducted network-based analy

SUBMITTER: Mohammadhassanzadeh H 

PROVIDER: S-EPMC8207474 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature