Cool OtOprotective Ear Lumen (COOL) Therapy for Cisplatin-induced Hearing Loss.

ABSTRACT:

Hypothesis

Localized cooling of the external ear has a protective effect on the susceptibility to cisplatin-induced hearing loss.

Background

We previously demonstrated significant protection from cisplatin-induced hearing loss using cool water ear canal irrigation. However, the study was limited to a single bolus injection of cisplatin and an acute time period. Here, we examined the application of localized cooling of the ear canal with repeated doses of cisplatin, over an expanded period of time, and using two methods of cooling.

Methods

Twenty-four guinea pigs (12 male and 12 female) underwent auditory physiological testing (auditory brainstem response and distortion product otoacoustic emissions at 8-32 kHz) and pre/postadministration of cisplatin. Cisplatin (4 mg/

SUBMITTER: Stanford JK 

PROVIDER: S-EPMC8207522 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature