Cellular and humoral immune responses associated with protection in sheep vaccinated against Teladorsagia circumcincta.

ABSTRACT: Due to increased anthelmintic resistance, complementary methods to drugs are necessary to control gastrointestinal nematodes (GIN). Vaccines are an environmentally-friendly and promising option. In a previous study, a Teladorsagia circumcincta recombinant sub-unit vaccine was administered to two sheep breeds with different levels of resistance against GIN. In the susceptible Canaria Sheep (CS) breed, vaccinates harboured smaller worms with fewer eggs in utero than the control group. Here, we extend this work, by investigating the cellular and humoral immune responses of these two sheep breeds following vaccination and experimental infection with T. circumcincta. In the vaccinated CS group, negative associations between antigen-specific IgA, IgG₂ and Globule Leukocytes (GLs) with

SUBMITTER: Machin C 

PROVIDER: S-EPMC8207578 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature