Metabolome analysis reveals a diversity of cancer tissues in advanced epithelial ovarian cancer.

ABSTRACT:

Background

Epithelial ovarian cancer remains one of the leading causes of cancer deaths among women worldwide, and advanced epithelial ovarian cancer frequently metastasizes to the omentum. The characteristics of metastatic cancer may differ from those of primary ovarian cancer and reflect the unique omental microenvironment. This study investigated metabolomic differences in epithelial ovarian cancers.

Methods

Patients with advanced epithelial ovarian cancer were eligible for this study. Five patients underwent surgery and resection of paired primary ovarian and omental metastatic cancer at Nagoya University. Metabolome analysis was performed in these paired cancer and metastatic cancer tissues through a facility service (C-SCOPE) at Human Metabolome Technologies, Inc. The

SUBMITTER: Yoshida K 

PROVIDER: S-EPMC8207638 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature