Involvement of TRPC5 channels, inwardly rectifying K⁺ channels, PLCβ and PIP₂ in vasopressin-mediated excitation of medial central amygdala neurons.

ABSTRACT:

Key points

Activation of V_1a vasopressin receptors facilitates neuronal excitability in the medial nucleus of central amygdala (CeM) V_1a receptor activation excites about 80% CeM neurons by opening a cationic conductance and about 20% CeM neurons by suppressing an inwardly rectifying K⁺ (Kir) channel The cationic conductance activated by V_1a receptors is identified as TRPC5 channels PLCβ-mediated depletion of PIP₂ is involved in V_1a receptor-elicited excitation of CeM neurons Intracellular Ca²⁺ release and PKC are unnecessary for V_1a receptor-mediated excitation of CeM neurons ABSTRACT: Arginine vasopressin (AVP) serves as a hormone in the periphery to modulate water homeostasis and a neuromodul

SUBMITTER: Boyle CA 

PROVIDER: S-EPMC8207704 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature