Cardioprotective effect of nicorandil on isoproterenol induced cardiomyopathy in the Mdx mouse model.

ABSTRACT:

Background

Duchenne muscular dystrophy (DMD) associated cardiomyopathy is a major cause of morbidity and mortality. In an in vitro DMD cardiomyocyte model, nicorandil reversed stress-induced cell injury through multiple pathways implicated in DMD. We aimed to test the efficacy of nicorandil on the progression of cardiomyopathy in mdx mice following a 10-day treatment protocol.

Methods

A subset of mdx mice was subjected to low-dose isoproterenol injections over 5 days to induce a cardiac phenotype and treated with vehicle or nicorandil for 10 days. Baseline and day 10 echocardiograms were obtained to assess cardiac function. At 10 days, cardiac tissue was harvested for further analysis, which included histologic analysis and assessment of oxidative stress. Paired student's t

SUBMITTER: Sullivan RT 

PROVIDER: S-EPMC8207777 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature