Entry of antiepileptic drugs (valproate and lamotrigine) into the developing rat brain.

ABSTRACT: Background: Women with epilepsy face difficult choices whether to continue antiepileptic drug treatment during pregnancy, as uncontrolled seizures carry great risk to mother and fetus but continuing treatment may have adverse effects on baby's development. This study aimed at evaluating antiepileptic drug entry into developing brain. Methods: Anaesthetised pregnant, non-pregnant adult females, postnatal and fetal rats were injected intraperitoneally with different doses, single or in combinations, of valproate and lamotrigine, within clinical range. Injectate included  ³H-labelled drug. After 30min, CSF, blood and brain samples were obtained; radioactivity measured using liquid scintillation counting. Some animals were also exposed to valproate in feed throughout p

SUBMITTER: Toll SJ 

PROVIDER: S-EPMC8207807 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature