Development of a harmonized patient-reported outcome questionnaire to assess myelofibrosis symptoms in clinical trials.

ABSTRACT: Along with reducing spleen size, relieving symptom severity is a key objective of the treatment of myelofibrosis (MF). Several questionnaires have been developed for patient self-report of MF symptoms in clinical trials and each includes unique instructions, items, and/or response scales. This variability in questionnaire content increases uncertainty; it is unclear which questionnaire is the most appropriate for assessing MF symptoms and it makes comparisons across trials difficult. The Patient-Reported Outcome (PRO) Consortium's MF Working Group (WG) was established to review existing MF symptom questionnaires and to develop a harmonized, consensus-based PRO questionnaire for use in future MF trials. The WG focused on the seven core symptoms of MF: fatigue, night sweats, pruritus, abdomi

SUBMITTER: Gwaltney C 

PROVIDER: S-EPMC8207823 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature