The optimal cutoff of atrial high-rate episodes for neurological events in patients with dual chamber permanent pacemakers.

ABSTRACT:

Background

Patients with atrial high-rate episode (AHRE) are at higher risk of neurological events. This study aimed to identify the optimal cutoff threshold for AHRE duration in patients with dual chamber permanent pacemakers (PPM) without prior atrial fibrillation.

Methods

We included 355 consecutive patients receiving dual chamber pacemaker implantation. Primary outcome was composite endpoint of subsequent neurological events after various AHRE durations. AHRE was defined as >175 bpm (MEDTRONIC) or > 200 bpm (BIOTRONIK) for longer than 30 s. Cox regression analysis with time-dependent covariates was conducted.

Results

The mean age of included patients was 75.6 ± 11.3 years. Among 355 included patients, some had multiple AHREs; 125 patients (35.2%) developed AHRE ≥2

SUBMITTER: Lu WD 

PROVIDER: S-EPMC8207987 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature