GABPα and CREB1 Binding to Double Nucleotide Polymorphisms of Their Consensus Motifs and Cooperative Binding to the Composite ETS ⇔ CRE Motif (ACCGGAAGTGACGTCA).

ABSTRACT: Previously, cooperative binding of the bZIP domain of CREB1 and the ETS domain of GABPα was observed for the composite DNA ETS ⇔ CRE motif (A ⁰ C ¹ C ² G ³ G ⁴ A ⁵ A ⁶ G ⁷ T ⁸ G ⁹ A ¹⁰ C ¹¹ G ¹² T ¹³ C ¹⁴ A ¹⁵ ). Single nucleotide polymorphisms (SNPs) at the beginning and end of the ETS motif (ACCGGAAGT) increased cooperative binding. Here, we use an Agilent microarray of 60-mers containing

SUBMITTER: Assad N 

PROVIDER: S-EPMC8208074 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature