A proteome signature for acute incisional pain in dorsal root ganglia of mice.

ABSTRACT:

Abstract

After surgery, acute pain is still managed insufficiently and may lead to short-term and long-term complications including chronic postsurgical pain and an increased prescription of opioids. Thus, identifying new targets specifically implicated in postoperative pain is of utmost importance to develop effective and nonaddictive analgesics. Here, we used an integrated and multimethod workflow to reveal unprecedented insights into proteome dynamics in dorsal root ganglia (DRG) of mice after plantar incision (INC). Based on a detailed characterization of INC-associated pain-related behavior profiles, including a novel paradigm for nonevoked pain, we performed quantitative mass-spectrometry-based proteomics in DRG 1 day after INC. Our data revealed a hitherto unknown INC-regula

SUBMITTER: Pogatzki-Zahn EM 

PROVIDER: S-EPMC8208099 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature