Spinoparabrachial projection neurons form distinct classes in the mouse dorsal horn.

ABSTRACT:

Abstract

Projection neurons in the spinal dorsal horn relay sensory information to higher brain centres. The activation of these populations is shaped by afferent input from the periphery, descending input from the brain, and input from local interneuron circuits. Much of our recent understanding of dorsal horn circuitry comes from studies in transgenic mice; however, information on projection neurons is still based largely on studies in monkey, cat, and rat. We used viral labelling to identify and record from mouse parabrachial nucleus (PBN) projecting neurons located in the dorsal horn of spinal cord slices. Overall, mouse lamina I spinoparabrachial projection neurons (SPBNs) exhibit many electrophysiological and morphological features that overlap with rat. Unbiased cluster anal

SUBMITTER: Browne TJ 

PROVIDER: S-EPMC8208100 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature