Fractal biomarker of activity in patients with bipolar disorder.

ABSTRACT:

Background

The output of many healthy physiological systems displays fractal fluctuations with self-similar temporal structures. Altered fractal patterns are associated with pathological conditions. There is evidence that patients with bipolar disorder have altered daily behaviors.

Methods

To test whether fractal patterns in motor activity are altered in patients with bipolar disorder, we analyzed 2-week actigraphy data collected from 106 patients with bipolar disorder type I in a euthymic state, 73 unaffected siblings of patients, and 76 controls. To examine the link between fractal patterns and symptoms, we analyzed 180-day actigraphy and mood symptom data that were simultaneously collected from 14 patients.

Results

Compared to controls, patients showed excessive re

SUBMITTER: Knapen SE 

PROVIDER: S-EPMC8208237 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature